Curriculum

Articoli pubblicati	68 (source: Pubmed, Scopus) – May, 20th, 2021.
Metriche	Impact Factor: >200 (Clarivate Analytics);  H-index: 19; citations: 1059 (source: Scopus)
Publication List (International peer-reviewed Journals)	1.   Scuruchi, M., D’Ascola, A, Avenoso, A, Mandraffino, G., Campo, S., Campo, G.M., Endocan, a novel inflammatory marker, is upregulated in human chondrocytes stimulated with IL-1 beta. Molecular and Cellular Biochemistry; Volume 476, Issue 3, March 2021, Pages 1589-1597 2.   Lilia Oreto, Gian Luca Vita, Giuseppe Mandraffino, Scipione Carerj, Maria Pia Calabrò, Roberta Manganaro, Maurizio Cusmà-Piccione, Maria Chiara Todaro, Maria Sframeli, Maria Cinquegrani, Antonio Toscano, Giuseppe Vita, Sonia Messina, Concetta Zito. Impaired myocardial strain in early stage of Duchenne muscular dystrophy: its relation with age and motor performance. Acta Myol. 2020 Dec 1;39(4):191-199. doi: 10.36185/2532-1900-022. eCollection 2020 Dec. 3.   Avenoso A, Campo S, Scuruchi M, Mania M, Innao V, D'Ascola A, Mandraffino G, Allegra AG, Musolino C, Allegra A. Quantitative polymerase Chain reaction profiling of microRNAs in peripheral lymph-monocytes from MGUS subjects. Pathol Res Pract. 2020 Dec 13;218:153317. doi: 10.1016/j.prp.2020.153317. Online ahead of print.PMID: 33360970 4.   Casula M, Gazzotti M, Bonaiti F, OImastroni E, Arca M, Averna M, Zambon A, Catapano AL; PROSISA Study Group. Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study. J Intern Med. 2020 Dec 1. doi: 10.1111/joim.13219. Online ahead of print. PMID: 33259671 5.   D'Ascola A, Scuruchi M, Ruggeri RM, Avenoso A, Mandraffino G, Vicchio TM, Campo S, Campo GM. Hyaluronan oligosaccharides modulate inflammatory response, NIS and thyreoglobulin expression in human thyrocytes. Arch Biochem Biophys. 2020 Nov 15;694:108598. doi: 10.1016/j.abb.2020.108598. Epub 2020 Sep 22. PMID: 32976824 6.   Avenoso A, D'Ascola A, Scuruchi M, Mandraffino G, Campo S, Campo GM. miR146a up-regulation is involved in small HA oligosaccharides-induced pro-inflammatory response in human chondrocytes. Biochim Biophys Acta Gen Subj. 2021 Jan;1865(1):129731. doi: 10.1016/j.bbagen.2020.129731. Epub 2020 Sep 12. PMID: 32931869 7.   Mandraffino, G., Scicali, R., Squadrito, G. Author's reply to: Arterial stiffness improvement after adding on PCSK9 inhibitors in patients with familial hypercholesterolemia, a letter from Papaioannou and colleagues. Journal of Clinical Lipidology, 2020. Volume 14, Issue 4, July - August 2020, Page 543 8.  Mandraffino G, Imbalzano E, Lo Gullo A, Zito C, Morace C, Cinquegrani M, Savarino F, Oreto L, Giuffrida C, Carerj S, Squadrito G. Abnormal left ventricular global strain during exercise-test in young healthy smokers. Sci Rep. 2020 Mar 30;10(1):5700. doi: 10.1038/s41598-020-62428-7. PMID: 32231243 Free Article 9.   Lo Gullo A, Rodríguez-Carrio J, Gallizzi R, Imbalzano E, Squadrito G, Mandraffino G. Speckle tracking echocardiography as a new diagnostic tool for an assessment of cardiovascular disease in rheumatic patients. Prog Cardiovasc Dis. 2020 Mar 19. pii: S0033-0620(20)30057-8. doi: 10.1016/j.pcad.2020.03.005. [Epub ahead of print] Review. PMID: 32201285 10.       Mandraffino G., Scicali R, Rodríguez-Carrio J, Savarino F, Mamone F, Scuruchi M, Cinquegrani M, Imbalzano E, Di Pino A, Piro S, Rabuazzo AM, Squadrito G, Purrello F, Saitta A. Arterial stiffness improvement following adding-on PCSK9 inhibitors or ezetimibe to high intensity statins in familial hypercholesterolemia patients: a two lipid center real-world experience. Journal of Clinical Lipidology. 2020. S1933-2874(20)30015-5. DOI: 10.1016/j.jacl.2020.01.015 11. Scuruchi, M., Potì, F., Rodríguez-Carrio, J., Campo, G.M., Mandraffino, G. Biglycan and atherosclerosis: Lessons from high cardiovascular risk conditions. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2020. 1865(2),158545 12.Avenoso A, Bruschetta G, D Ascola A, Scuruchi M, Mandraffino G, Saitta A, Campo S, Campo GM. Hyaluronan Fragmentation During Inflammatory Pathologies: A Signal That Empowers Tissue Damage. Mini Rev Med Chem. 2020 Sep 6. doi: 20(1), pp. 54-65. PMID: 31490750 13.Avenoso A, Bruschetta G, D'Ascola A, Scuruchi M, Mandraffino G, Gullace R, Saitta A, Campo S, Campo GM. Hyaluronan fragments produced during tissue injury: A signal amplifying the inflammatory response. Arch Biochem Biophys. 2019 Mar 15;663:228-238. doi: 10.1016/j.abb.2019.01.015. Epub 2019 Jan 19. Review. PubMed PMID: 30668938.  14.Basile G, Catalano A, Mandraffino G, Maltese G, Alibrandi A, Ciancio G, Brischetto D, Morabito N, Lasco A, Cesari M. Frailty modifications and prognostic impact in older patients admitted in acute care. Aging Clin Exp Res. 2019 Jan;31(1):151-155. doi: 10.1007/s40520-018-0989-7. Epub 2018 Jun 26. PubMed PMID:29946755. 15.Scuruchi M, D'Ascola A, Avenoso A, Mandraffino G., Campo S., Campo GM. Serglycin as part of IL-1β induced inflammation in human chondrocytes. Arch Biochem Biophys. 2019 Jul 15;669:80-86. doi: 10.1016/j.abb.2019.05.021. Epub 2019 May 27. PMID: 31145901 16.Mandraffino G, Saitta A. Endothelial and Circulating Progenitor Cells: Between Diseases and Therapies. Curr Med Chem. 2018;25(35):4476-4477. Doi:10.2174/092986732535181026143801. PubMed PMID: 30563440. 17. Imbalzano E, Vatrano M, Ghiadoni L, Mandraffino G, Dalbeni A, Khandheria BK, Costantino R, Trapani G, Manganaro R, Cusmà Piccione M, Carerj S, Ceravolo R, Saitta A, Zito C. Arterial stiffness and mitral regurgitation in arterial hypertension: an intriguing pathophysiological link. Vascul Pharmacol. 2018 Dec;111:71-76. doi: 10.1016/j.vph.2018.10.007. Epub 2018 Oct 22. PubMed PMID:30359778.  18.       Casula M, Olmastroni E, Pirillo A, Catapano AL; MEMBERS OF THE LIPIGEN STEERING COMMETTEE; PRINCIPAL INVESTIGATORS: Coordinator center; Participant Centers; Participant Laboratories; COLLABORATORS; STUDY CENTRAL LABORATORY AND ANALYSIS GROUP. Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study. Atherosclerosis. 2018 Oct;277:413-418. doi: 10.1016/j.atherosclerosis.2018.08.013. PubMed PMID: 30270079. 19.Lo Gullo A, Aragona CO, Scuruchi M, Versace AG, Saitta A, Imbalzano E, Loddo S, Campo GM, Mandraffino G. Endothelial progenitor cells and rheumatic disease modifying therapy. Vascul Pharmacol. 2018 Sep;108:8-14. doi:10.1016/j.vph.2018.05.007. Epub 2018 May 26. Review. PubMed PMID: 29842927. 20.      Muto P, Lo Gullo A, Mandraffino G, Loddo S, Atteritano M. High levels of serum sclerostin and DKK1 in a case of Klippel-Trénaunay syndrome. Osteoporos Int. 2018 Jul;29(7):1679-1681. doi: 10.1007/s00198-018-4563-0. Epub 2018 May 17. PubMed PMID: 29774401. 21.Giardina C, Cutroneo PM, Mocciaro E, Russo GT, Mandraffino G, Basile G, Rapisarda F, Ferrara R, Spina E, Arcoraci V. Adverse Drug Reactions in Hospitalized Patients: Results of the FORWARD (Facilitation of Reporting in Hospital Ward) Study. Front Pharmacol. 2018 Apr 11;9:350. doi: 10.3389/fphar.2018.00350. eCollection 2018. PubMed PMID: 29695966; PubMed Central PMCID: PMC5904209. 22.       D'Ascola A, Scuruchi M, Avenoso A, Bruschetta G, Campo S, Mandraffino G, Campo GM. Serglycin is involved in inflammatory response in articular mouse chondrocytes. Biochem Biophys Res Commun. 2018 May 15;499(3):506-512. doi:10.1016/j.bbrc.2018.03.178. Epub 2018 Mar 31. PubMed PMID: 29588174.  23.       Lo Gullo A, Rodríguez-Carrio J, Aragona CO, Dattilo G, Zito C, Suárez A, Loddo S, Atteritano M, Saitta A, Mandraffino G. Subclinical impairment of myocardial and endothelial functionality in very early psoriatic and rheumatoid arthritis patients: Association with vitamin D and inflammation. Atherosclerosis. 2018 Apr;271:214-222. doi: 10.1016/j.atherosclerosis.2018.03.004. Epub 2018 Mar 2. PubMed PMID: 29524864. 24.       Imbalzano E, Vatrano M, Quartuccio S, Ceravolo R, Ciconte VA, Rotella P, Pardeo R, Trapani G, De Fazio P, Segura-Garcia C, Costantino R, Saitta A, Mandraffino G. Effect of type D personality on smoking status and their combined impact on outcome after acute myocardial infarction. Clin Cardiol. 2018 Mar;41(3):321-325. doi: 10.1002/clc.22865. Epub 2018 Feb 19. PubMed PMID:29457844. 25.       Avenoso A, D'Ascola A, Scuruchi M, Mandraffino G, Calatroni A, Saitta A, Campo S, Campo GM. Hyaluronan in experimental injured/inflamed cartilage: In vivo studies. Life Sci. 2018 Jan 15;193:132-140. doi: 10.1016/j.lfs.2017.11.006. Epub 2017 Nov 7. Review. PubMed PMID: 29126884. 26.       Avenoso A, D'Ascola A, Scuruchi M, Mandraffino G, Calatroni A, Saitta A, Campo S, Campo GM. The proteoglycan biglycan mediates inflammatory response by activating TLR-4 in human chondrocytes: Inhibition by specific siRNA and high polymerized Hyaluronan. Arch Biochem Biophys. 2018 Jan 13;640:75-82. doi: 10.1016/j.abb.2018.01.007. [Epub ahead of print] PubMed PMID: 29339093. 27.       Avenoso A, D'Ascola A, Scuruchi M, Mandraffino G, Calatroni A, Saitta A, Campo S, Campo GM. Hyaluronan in the experimental injury of the cartilage: biochemical action and protective effects. Inflamm Res. 2018 Jan;67(1):5-20. doi: 10.1007/s00011-017-1084-9. Epub 2017 Aug 12. Review. PubMed PMID: 28803264. 28.      Basile G, Catalano A, Mandraffino G, Maltese G, Alibrandi A, Ciancio G, Lasco A, Cesari M. Relationship between blood pressure and frailty in older hypertensive outpatients. Aging Clin Exp Res. 2017 Oct;29(5):1049-1053. doi: 10.1007/s40520-016-0684-5. Epub 2016 Nov 21. PubMed PMID: 27873101. 29.       Pirillo A, Garlaschelli K, Arca M, Averna M, Bertolini S, Calandra S, Tarugi P, Catapano AL; LIPIGEN Group. Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study. Atheroscler Suppl. 2017 Oct;29:17-24. doi: 10.1016/j.atherosclerosissup.2017.07.002. PubMed PMID: 28965616. 30.      Averna M, Cefalù AB, Casula M, Noto D, Arca M, Bertolini S, Calandra S, Catapano AL, Tarugi P; LIPIGEN Group. Familial hypercholesterolemia: The Italian Atherosclerosis Society Network (LIPIGEN). Atheroscler Suppl. 2017 Oct;29:11-16. doi: 10.1016/j.atherosclerosissup.2017.07.001. PubMed PMID: 28965615.  31.Oreto L, Mandraffino G, Manuri L, Saitta MB, Agati S, Zito C, Iorio FS, Carerj S, Guccione P. Atrial septal defect morphology and stenting in hypoplastic left heart syndrome after hybrid palliation. Cardiol Young. 2017 Sep 11:1-9. doi: 10.1017/S1047951117001792. [Epub ahead of print] PubMed PMID: 28889828.  32.       Laufs U, Filipiak KJ, Gouni-Berthold I, Catapano AL; SAMS expert working group (Mandraffino G; Benlian P). Practical aspects in the management of statin-associated muscle symptoms (SAMS). Atheroscler Suppl. 2017 Apr;26:45-55. doi: 10.1016/S1567-5688(17)30024-7. PubMed PMID: 28434484. 33.       Mandraffino G, Cairo V, Saitta A. Current challenges on circulating progenitor cells: Could their number predict oncoming diseases? Atherosclerosis. 2017 Mar 31. pii: S0021-9150(17)30140-5. doi: 10.1016/j.atherosclerosis.2017.03.037. [Epub ahead of print] PubMed PMID: 28389015. 34.       Mandraffino G, Aragona CO, Scuruchi M, Mamone F, D'Ascola A, Alibrandi A, Cinquegrani M, Morace C, Oreto L, Saitta C, Mormina E, Carerj S, Saitta A, Imbalzano E. Biglycan expression, earlier vascular damage and pro-atherogenic profile improvement after smoke cessation in young people. Atherosclerosis. 2017 Jan 16;257:109-115. doi: 10.1016/j.atherosclerosis.2017.01.012. [Epub ahead of print] PubMed PMID: 28131044.  35.       Mandraffino G, Aragona CO, Basile G, Cairo V, Mamone F, Morace C, D'Ascola A, Alibrandi A, Lo Gullo A, Loddo S, Saitta A, Imbalzano E. CD34+ cell count predicts long lasting life in the oldest old. Mech Ageing Dev. 2017 Mar 16. pii: S0047-6374(17)30061-1. doi: 10.1016/j.mad.2017.03.003. [Epub ahead of print] PubMed PMID: 28322848. 36.       Mandraffino G, Aragona CO, Cairo V, Scuruchi M, Lo Gullo A, D'Ascola A, Alibrandi A, Loddo S, Quartuccio S, Morace C, Mormina E, Basile G, Saitta A, Imbalzano E. Circulating progenitor cells in hypertensive subjects: Effectiveness of a treatment with olmesartan in improving cell number and miR profile in addition to expected pharmacological effects. PLoS One. 2017 Mar 16;12(3):e0173030. doi: 10.1371/journal.pone.0173030. eCollection 2017. PubMed PMID: 28301500; PubMed Central PMCID: PMC5354372. 37.       Manuri L, Morelli S, Agati S, Saitta MB, Oreto L, Mandraffino G, Iannace E, Iorio FS, Guccione P. Early hybrid approach and enteral feeding algorithm could reduce the incidence of necrotising enterocolitis in neonates with ductus-dependent systemic circulation. Cardiol Young. 2017 Jan;27(1):154-160. doi: 10.1017/S1047951116000275. PubMed PMID: 28281412. 38.      Imbalzano E, Vatrano M, Quartuccio S, Di Stefano R, Aragona CO, Mamone F, D'Ascola A, Scuruchi M, Felice F, Trapani G, Alibrandi A, Ciconte VA, Ceravolo R, Saitta A, Mandraffino G. Clinical impact of angiotensin I converting enzyme polymorphisms in subjects with resistant hypertension. Mol Cell Biochem. 2017 Feb 11. doi: 10.1007/s11010-017-2957-5. [Epub ahead of print] PubMed PMID: 28190172. 39.       Lo Gullo A, Mandraffino G, Aragona CO, Molica Colella A, Saitta A, Imbalzano E. Subcutaneous administration of tocilizumab is effective in myointimal hyperplasia remodelling in refractory Takayasu arteritis. Reumatismo. 2017 Dec 21;69(4):184-188. doi: 10.4081/reumatismo.2017.1013. PMID: 29320845  40.      Mandraffino G, Aragona CO, Imbalzano E. Surrogate markers of HDL functionality and arterial stiffening: Which role in rheumatoid arthritis? Atherosclerosis. 2016 Jul 5. pii: S0021-9150(16)30301-X. doi: 10.1016/j.atherosclerosis.2016.07.002. 41.Caterina Oriana Aragona, Egidio Imbalzano, Federica Mamone, Valentina Cairo, Alberto Lo Gullo, Angela D’Ascola, Maria Adriana Sardo, Michele Scuruchi, Giorgio Basile, Antonino Saitta, and Giuseppe Mandraffino. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease, Stem Cells International Volume 2016 (2016), Article ID 8043792, 12 pages; DOI: 10.1155/2016/8043792. 42.       Egidio Imbalzano, Giuseppe Mandraffino, Marco Casciaro, Sebastiano Quartuccio, Antonino Saitta, Sebastiano Gangemi. Pathophysiological mechanism and therapeutic role of S100 proteins in cardiac failure: a systematic review. Heart Fail Rev. DOI: 10.1007/s10741-016-9529-8. 43.       Lo Gullo A, Aragona CO, Ardesia M, Versace AG, Cascio A, Saitta A, Mandraffino G. A Strongyloides stercoralis infection presenting as arthritis of sternoclavicular joint. Mod Rheumatol. 2016 Nov;26(6):981-983. doi:10.3109/14397595.2015.1132954. Epub 2016 Feb 16. PubMed PMID: 26709048. 44.       Minciullo PL, Catalano A, Mandraffino G, Casciaro M, Crucitti A, Maltese G, Morabito N, Lasco A, Gangemi S, Basile G. Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity. Arch Immunol Ther Exp (Warsz). 2015 Dec 12. [Epub ahead of print] PubMed PMID: 26658771. 45.       Lo Gullo A, Mandraffino G, Bagnato G, Aragona CO, Imbalzano E, D'Ascola A, Rotondo F, Cinquegrani A, Mormina E, Saitta C, Versace AG, Sardo MA, Lo Gullo R, Loddo S, Saitta A. Vitamin D Status in Rheumatoid Arthritis: Inflammation, Arterial Stiffness and Circulating Progenitor Cell Number. PLoS One. 2015 Aug 4;10(8):e0134602. doi: 10.1371/journal.pone.0134602. eCollection 2015. PubMed PMID: 26241902; PubMed Central PMCID: PMC4524708. 46.      Imbalzano E, Vatrano M, Mandraffino G, Ghiadoni L, Gangemi S, Bruno RM, Ciconte VA, Paunovic N, Costantino R, Mormina EM, Ceravolo R, Saitta A, Dattilo G. Arterial stiffness as a predictor of recovery of left ventricular systolic function after acute myocardial infarction treated with primary percutaneous coronary intervention. Int J Cardiovasc Imaging. 2015 Dec;31(8):1545-51. doi: 10.1007/s10554-015-0733-8. Epub 2015 Aug 4. PubMed PMID: 26239135. 47.       Basile G, Catalano A, Mandraffino G, Crucitti A, Ciancio G, Morabito N, Lasco A. Cognitive Impairment and Slow Gait Speed in Elderly Outpatients with Arterial Hypertension: The Effect of Blood Pressure Values. J Am Geriatr Soc. 2015 Jun;63(6):1260-1. doi: 10.1111/jgs.13495. PubMed PMID: 26096407. 48.      Vatrano M, Dattilo G, Mandraffino G, Gangemi S, Ciconte VA, Quartuccio S, Ceravolo R, Imbalzano E. A quick bailout ongoing of cardiogenic shock and iatrogenic dissection of the left main coronary artery. Int J Cardiol. 2015 Apr 1;184:473-4. doi: 10.1016/j.ijcard.2015.03.001. Epub 2015 Mar 3. PubMed PMID: 25756567.  49.       Mandraffino G, Imbalzano E, Mamone F, Aragona CO, Lo Gullo A, D'Ascola A, Alibrandi A, Cinquegrani A, Mormina E, Versace A, Basile G, Sardo MA, Cinquegrani M, Carerj S, Saitta A. Biglycan expression in current cigarette smokers: a possible link between active smoking and atherogenesis. Atherosclerosis. 2014 Dec;237(2):471-9. doi: 10.1016/j.atherosclerosis.2014.10.024. Epub 2014 Oct 18. PubMed PMID: 25463076. 50.      Lo Gullo A, Mandraffino G, Imbalzano E, Mamone F, Aragona CO, D'Ascola A, Loddo S, Cinquegrani A, Alibrandi A, Mormina E, Bagnato G, Lo Gullo R, Sardo MA, Saitta A. Toll-like receptor 3 and interleukin 1β expression in CD34+ cells from patients with rheumatoid arthritis: association with inflammation and vascular involvement. Clin Exp Rheumatol. 2014 Nov-Dec;32(6):922-9. Epub 2014 Nov 7. PubMed PMID: 25436985. 51.Imbalzano E, Scarpelli M, Mandraffino G, Creazzo M, Lizio G, Trapani G, Dattilo G, Dalbeni A, Tomasello C, Sardo MA, Saitta A. Combination therapy with aliskiren versus ramipril or losartan added to conventional therapy in patients with type 2 diabetes mellitus, uncontrolled hypertension and microalbuminuria. J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):956-64. doi: 10.1177/1470320314530018. Epub 2014 Jul 27. PubMed PMID: 25070350. 52.  Imbalzano E, Mandraffino G, Ceravolo R, Di Stefano R, Saitta A. Renal denervation rapidly restores circulating proangiogenic hematopoietic cells in patients affected by drug-resistant hypertension. Int J Cardiol. 2014 May 15;173(3):591-2. doi: 10.1016/j.ijcard.2014.03.100. Epub 2014 Mar 21. PubMed PMID: 24698255. 53.  Imbalzano E, Casale M, D'Angelo M, Mandraffino G, Giugno V, Di Bella G, Carerj S, Dattilo G. Cardiovascular risk and psoriasis: a role in clinical cardiology? Angiology. 2015 Feb;66(2):101-3. doi: 10.1177/0003319714527339. Epub 2014 Mar 25. Review. PubMed PMID: 24671131. 54.  Mandraffino G, Imbalzano E, Sardo MA, D'Ascola A, Mamone F, Lo Gullo A, Alibrandi A, Loddo S, Mormina E, David A, Saitta A. Circulating progenitor cells in hypertensive patients with different degrees of cardiovascular involvement. J Hum Hypertens. 2014 Sep;28(9):543-50. doi: 10.1038/jhh.2014.7. Epub 2014 Feb 20. PubMed PMID: 24553637. 55.  Mandraffino G, Dalbeni A, Paunovic N, Mormina EM, Imbalzano E. Radiation-induced heart and vessel atherosclerosis disease. Int J Cardiol. 2014 Mar 15;172(2):505-6. doi: 10.1016/j.ijcard.2014.01.059. Epub 2014 Jan 23. PubMed PMID: 24485624. 56.  Imbalzano E, Saitta A, Lamari A, Trapani G, Lizio G, Creazzo M, Mandraffino G, Scarano M, Dattilo G. [Echo-Doppler evaluation of recent onset chronic venous insufficiency in elderly patients: does the heart have a role?]. Recenti Prog Med. 2013 Nov;104(11):569-73. doi: 10.1701/1370.15226. Italian. PubMed PMID: 24336618. 57.  Lo Gullo A, Mandraffino G, Sardo MA, D'Ascola A, Mamone F, Loddo S, Alibrandi A, Imbalzano E, Mandraffino R, Mormina E, Saitta C, Lo Gullo R, David A, Saitta A. Circulating progenitor cells in rheumatoid arthritis: association with inflammation and oxidative stress. Scand J Rheumatol. 2014;43(3):184-93. doi: 10.3109/03009742.2013.836564. Epub 2013 Dec 9. PubMed PMID: 24313545. 58. Imbalzano E, Creazzo M, Mandraffino G, Sardo MA, Saitta A. Treatment failure of low molecular weight heparin in post-surgery orthopedic case. Int J Cardiol. 2013 Nov 5;169(3):e36-7. doi: 10.1016/j.ijcard.2013.08.109. Epub 2013 Sep 8. PubMed PMID: 24063927. 59.  Mandraffino G, Sardo MA, Riggio S, D'Ascola A, Alibrandi A, Saitta C, Versace A, Castaldo M, Mormina E, Imbalzano E, Cinquegrani M, Bonaiuto M, David A, Saitta A. Circulating progenitor cells and the elderly: a seven-year observational study. Exp Gerontol. 2012 May;47(5):394-400. doi: 10.1016/j.exger.2012.03.007. Epub 2012 Mar 17. PubMed PMID: 22449458. 60. Imbalzano E, Zito C, Carerj S, Oreto G, Mandraffino G, Cusmà-Piccione M, Di Bella G, Saitta C, Saitta A. Left ventricular function in hypertension: new insight by speckle tracking echocardiography. Echocardiography. 2011 Jul;28(6):649-57. doi: 10.1111/j.1540-8175.2011.01410.x. Epub 2011 Jun 15. PubMed PMID: 21676016. 61.  Mandraffino G, Sardo MA, Riggio S, Loddo S, Imbalzano E, Alibrandi A, Saitta C, Cinquegrani M, Mormina EM, Saitta A. Circulating progenitor cells are increased in newly diagnosed untreated hypertensive patients with arterial stiffening but normal carotid intima-media thickness. Hypertens Res. 2011 Jul;34(7):876-83. doi: 10.1038/hr.2011.56. Epub 2011 May 19. PubMed PMID: 21593737. 62. Cascio A, Mandraffino G, Cinquegrani M, Delfino D, Mandraffino R, Romeo O, Criseo G, Saitta A. Actinomadura pelletieri mycetoma--an atypical case with spine and abdominal wall involvement. J Med Microbiol. 2011 May;60(Pt 5):673-6. doi: 10.1099/jmm.0.027862-0. Epub 2011 Jan 20. Review. PubMed PMID: 21252272. 63. Mandraffino G, Sardo MA, Riggio S, D'Ascola A, Loddo S, Alibrandi A, Saitta C, Imbalzano E, Mandraffino R, Venza M, Mormina EM, David A, Saitta A. Smoke exposure and circulating progenitor cells: evidence for modulation of antioxidant enzymes and cell count. Clin Biochem. 2010 Dec;43(18):1436-42. doi: 10.1016/j.clinbiochem.2010.09.023. Epub 2010 Sep 29. PubMed PMID: 20888331. 64. Riggio S, Mamone F, Mandraffino G, Maimone S, Alibrandi A, Manti L, Saitta C, Tripodi PF, Sardo MA, Squadrito G, Saitta A. Assessment of liver stiffness in subjects affected by familial combined hyperlipidaemia with hepatic steatosis. Eur J Clin Invest. 2010 Aug;40(8):722-8. doi: 10.1111/j.1365-2362.2010.02323.x. Epub 2010 Jun 14. PubMed PMID: 20561029. 65.  Sardo MA, Mandraffino G, Riggio S, D'Ascola A, Alibrandi A, Saitta C, Imbalzano E, Castaldo M, Cinquegrani M, Saitta A. Effects of the angiotensin II receptor blocker losartan on the monocyte expression of biglycan in hypertensive patients. Clin Exp Pharmacol Physiol. 2010 Sep;37(9):933-8. doi: 10.1111/j.1440-1681.2010.05407.x. Epub 2010 May 24. PubMed PMID: 20497421. 66. Riggio S, Mandraffino G, Sardo MA, Iudicello R, Camarda N, Imbalzano E, Alibrandi A, Saitta C, Carerj S, Arrigo T, Saitta A. Pulse wave velocity and augmentation index, but not intima-media thickness, are early indicators of vascular damage in hypercholesterolemic children. Eur J Clin Invest. 2010 Mar;40(3):250-7. doi: 10.1111/j.1365-2362.2010.02260.x. PubMed PMID: 20415700. 67.  Sardo MA, Mandraffino G, Campo S, Saitta C, Bitto A, Alibrandi A, Riggio S, Imbalzano E, Saitta A. Biglycan expression in hypertensive subjects with normal or increased carotid intima-media wall thickness. Clin Chim Acta. 2009 Aug;406(1-2):89-93. doi: 10.1016/j.cca.2009.05.024. Epub 2009 Jun 10. PubMed PMID: 19523462. 68.   Sardo MA, Campo S, Mandraffino G, Saitta C, Bonaiuto A, Castaldo M, Cinquegrani M, Pizzimenti G, Saitta A. Tissue factor and monocyte chemoattractant protein-1 expression in hypertensive individuals with normal or increased carotid intima-media wall thickness. Clin Chem. 2008 May;54(5):814-23. doi: 10.1373/clinchem.2007.095547. Epub 2008 Mar 13. PubMed PMID: 18339698.
Aknowledgments
Awarded oral Communication	27th (European) Meeting on Hypertension and Cardiovascular Protection Milan (Italy), June 16-19, 2017 (ESH): Efficacy of monoclonal antibodies anti-proprotein convertase subtilisin-kexin type 9 in improving lipid profile and arterial stiffness in patients affected by familial hypercholesterolemia; Oral Communication
Accommodation Grant Prize	26th (European) Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 (ESH): “Circulating progenitor cells in hypertension: effectiveness of a treatment with olmesartan in improving cell number and miRs profile besides expected pharmacological effects” Presenting author
Award for Best Poster Session  “Alberto Ferrari Poster Prize”	26th (European) Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 (ESH): “Circulating progenitor cells in hypertension: effectiveness of a treatment with olmesartan in improving cell number and miRs profile besides expected pharmacological effects” Presenting author
Best original contribution	Spring Meeting SISA/SIIA, Rimini, 11-12 March, 2016; section: Poster Contribution: AT1R blockade by Losartan as well as smoking cessation reduce Biglycan expression in uncomplicated subjects Presenting author
Travel Grant Prize	EAS European Congress, Innsbruck, May 29- June 1 2016; section: Poster Three original contributions Presenting author
Travel Grant Prize	EAS European Congress, Innsbruck, May 29- June 1 2016; section: Poster Three original contributions Co-author
Young Researcher Prizes (SISA Travel Grant)	Edizioni Congresso Nazionale SISA: 2006; 2007; 2009; 2010; 2011; 2012; 2013; 2014; 2015; 2016; 2017; 2018; 2019. Quattro volte premiato come presenting first author Sei volte premiato come non-presenting first author (co-primo) Dieci volte premiato come study coordinator author Nove volte premiato come non-presenting author
Last Update:  May, 20th, 2021

Curriculum

Curriculum Vitae

Personal information

First name(s) / Surname(s)

Giuseppe Mandraffino

Work Address(es)

Dipartimento di Medicina Clinica e Sperimentale V. Consolare Valeria Gazzi, University Hospital G. Martino

Telephone(s)

+39 0902212359

Mobile:

Fax(es)

+390902212372

E-mail

gmandraffino@unime.it or gmandraffinomd@libero.it

PEC

g.mandraffino-8901@pec.omceo.me.it

Nationality

Italian

Date of birth

May 11, 1980

Gender

Male

Current position

Academic

Senior Assistant Professor (Internal Medicine), University of Messina

Teachings

·       Single Cycle Master Degree: School of Medicine and Surgery,  University of Messina    ·       Medical Specialization Schools ·       Internal Medicine  ·       Geriatrics ·       Cardiology ·       Neurology ·       Hematology ·       Oftalmology ·       Thoracic Surgery  ·       Radiology ·       Pharmacology and Toxicology –medical course  ·       Pharmacology and Toxicology –nonmedical course   ·       PhD Course in Clinical and Experimental Medical Science (XXXII-XXXIII-XXXIV ciclo) ·       International PhD Course in Clinical and Experimental Medical Science    ·       School for specific formation in General Practionery (2018/2021) - Polo di Messina

Current teachings (2020-21) CdL Medicina e Chirurgia University of Messina

Internal Medicine (since AA 2014-15, current) Semeiotics e Clinical Methodology (since AA 2015-16, current) Emergency Medicine (since AA 2015-16, current)

Terminated teachings (AA 2014-2019)

AA 2016-17 e 2017-18: Rheumatology – CdL Medicina e Chirurgia AA 2016-17 e 2017-18: Rheumatology – CdL Scienze Infermieristiche AA 2017-18: Rheumatology – CdL Fisioterapia

Dissertation tutoring

Tutor for 30 Final Dissertations – MD in Medicine and Surgery  Tutor for 3 Final Dissertations – Specialization School in Internal Medicine Tutor for 1 Final Dissertation – MD in Nursing

Academic tasks (since 26.02.2018)

International Mobility Program, Master Degree in Medicine and Surgery

Assistential

Lipigen Lipid Center of Messina, Head; Unit of Internal Medicine

Formation

2009-2012

PhD   Clinical and Experimental Medicine [XXV ciclo]   University of Messina

2004-2009

Internal Medicine Specialist   University of Messina

1998-2004

MD, Medical Doctor   Master Degree in Medicine and Surgery    University of Messina

Personal skills and competences

Mother tongue(s)

Italian

Other language(s)

English, French

Self-assessment

Understanding

Speaking

Writing

European level (*)

Listening

Reading

Spoken interaction

Spoken production

English

C1

C2

C2

C2

C2

French

B1

C1

B1

A2

A1

(*) Common European Framework of Reference for Languages

Expert Panel

APEX (Atherosclerosis Prevention Scientific Exchange), member for “Practical aspects in the management of statin associated muscle symptoms (SAMS)” * *Laufs U, Filipiak KJ, Gouni-Berthold I, Catapano AL; SAMS expert working group (Mandraffino G; Benlian P.). Practical aspects in the management of statin-associated muscle symptoms (SAMS). Atheroscler Suppl. 2017 Apr; 26:45-55. doi: 10.1016/S1567-5688(17)30024-7. PMID: 28434484.

Advisory Board

·       “The clinical relevance of Odissey Outcomes data in real life”; Web Conference, 9 maggio 2019 - SANOFI ·       “L'acido Bempedoico come nuova opzione nel trattamento delle dislipidemie”, 26 Novembre 2020 – DAICHI-SANKYO  ·       “Q&A con l’HCP”; 15.01.2021 – NOVONORDISK

Scientific Societies membership

SISA/EAS; SIMI; ESH.

Societies board member

SISA (sez. “Siculo-Calabra”) (2015-2018, 2018-current) SISA – “GRUPPO GIOVANI” – National Board (former, 2016-2019)  SIMI (sez. Sicilia) (2019 – attuale)

Scientific activities,  (briefly)

Speaker/Chairman/Faculty at National, Regional and Interregional meetings by National and International Scientific Societies (SISA; SIMI, AMD/SID, SIC, AICPR, SIPMEL, EAS, ESH).   Scientific Committee for several scientific meetings: SISA National meetings, SISA Young Investigators meetings, SISA Siculo-Calabro meetings (both local and National coverage)    SIMI Sicily regional meetings, organization   Active SISA member since 2004; author/co-author of more than 70 original contributions so far, accepted as oral communication or poster presentation at National meetings (SISA National meeting; Spring Meeting).   Speaker/Lecturer in a number of training course for medical specialists and/or general practitioners on cardiovascular risk and dyslipidemia, including CME

Journal Editorial Board

Stem Cells International [ISSN: 1687-966X (Print), ISSN: 1687-9678 (Online]), IF 3.869, as Academic Editor https://www.hindawi.com/journals/sci/editors/ Frontiers in Cardiovascular Medicine [ISSN: 2297-055X], IF 3.915, as Review Editor in Cardiovascular Metabolism https://loop.frontiersin.org/people/192174/overview Current Medicinal Chemistry [ISSN 0929-8673], IF 3.894, as Guest Editor; https://www.eurekaselect.com/166678/article Biomolecules [EISSN 2218-273X, Published by MDPI] IF 4.082, as Guest Editor; https://www.mdpi.com/journal/biomolecules/special_issues/circulating_biomarkers_atherosclerosis Frontiers in Medicine [2296-858X] IF 3.9, as Guest Editor; "Chronic Rheumatic Inflammatory Conditions and Cardiovascular Health”, https://www.frontiersin.org/research-topics/20979/chronic-rheumatic-inflammatory-conditions-and-cardiovascular-health?utm_source=F-RTM&utm_medium=TED1&utm_campaign=PRD_TED1_T1_RT-TITLE

Peer Reviewing Activity

Ageing [ONLINE ISSN: 1945-4589] Atherosclerosis [ISSN:0021-9150 (Print); 1879-1484 (Electronic); 0021-9150 (Linking)] Biomedicine [EISSN 2227-9059, Published by MDPI] Biomolecules [EISSN 2218-273X, Published by MDPI] BMJ Open [ISSN 2044-6055] British Journal of Medicine and Medical Research [ISSN: 2231-0614] Cardiology Research and Practice [ISSN: 2090-8016 (Print); 2090-0597 (Online)] Cardiovascular Diabetology [ISSN: 1475-2840] Cell Transplantation: The Regenerative Medicine Journal [ISSN: 0963-6897; E-ISSN: 1555-3892] Clinical and Experimental Pharmacology and Physiology [ISSN: 1440-1681 - Online]  Disease Markers: [ISSN: 0278-0240 (Print), ISSN: 1875-8630 (Online)] European Heart Journal [ISSN: 0195-668X] European Journal of Preventive Cardiology [ISSN: 2047-4873 - Online ISSN: 2047-4881] Experimental and Therapeutic Medicine [ISSN: 1792-0981 - eISSN: 1792-1015] Frontiers in Cardiovascular Medicine [ISSN: 2297-055X] Hypertension Research [ISSN:0916-9636 -Print; 1348-4214 -Electronic; 0916- 9636 –Linking]  International Journal of Cardiology [ISSN: 0167-5273] International Journal of Molecular Medicine [Print ISSN: 1107-3756; Online ISSN: 1791-244X] International Journal of Molecular Science [EISSN 1422-0067, Published by MDPI ] International Journal of Rheumatic Diseases [ISSN: 1756-185X] Journal of Clinical Lipidology [ISSN: 1933-2874]  Journal of Human Hypertension [ISSN: 0950-9240 –Print; 1476-5527 - Electronic;0950-9240 –Linking]  Medical Principles and Practice [ISSN: 1011-7571 (Print) e-ISSN: 1423-0151 (Online)] Medicine [ISSN: 0025-7974 - Online ISSN: 1536-5964] Molecular and Cellular Biochemistry [ISSN: 0300-8177 (print); ISSN: 1573-4919 (electronic) Nicotine and Tobacco Research [ISSN 1462-2203 –Print; 1469-994X – Electronic; 1462-2203 –Linking]  Nutrition [ISSN: 0899-9007] Nutrition Metabolism and Cardiovascular Disease [ISSN: 0939-4753] Oncotarget [ISSN: 1949-2553] PLOS one [ISSN: 1932-6203 –Electronic; 1932-6203 –Linking]  Rheumatology [Online ISSN 1462-0332 - Print ISSN 1462-0324] Scandinavian Journal of Rheumatology [ISSN 0300-9742 (Print), 1502-7732 (Online)]  Scientifica: [ISSN 2090-908X (Online)]  The Open Rheumatology Journal [ISSN: 1874-3129]

Current investigations

Main research focus:  Lipids interaction with other cardiovascular risk factors: vascular and cardiac clinical and subclinical damage; mediators, markers, outcomes.  Endocan plasma levels in patients with Cardiovascular risk factors  Endocan plasma levels in patients with Rheumatoid arthritis Endocan plasma levels in patients with Psoriatic arthritis MicroRNA levels in patients with different conditions characterized by high cardiovascular risk MicroRNA before and after pharmacologic treatment CD34+ cells in peripheral blood in patients with different conditions characterized by high cardiovascular risk CD34+ cells in peripheral blood before and after pharmacologic treatment Lp(a) in different clinical conditions (metabolic syndrome, pregnancy, hyperlipidemia)  Lp(a) change during last frontier therapies: antiPCSK9 monoclonal antibodies Treatment with iPCSK9 and change in vascular mechanical properties, CD34+ cell number, vascular damage and signal molecules. Treatment with Sacubitril/valsartan and change in subtle mechanical properties of left ventricle

 

 

Invited speaker (Scientific Societies)

SIMI: VIII Congresso Regionale Della Societa’ Italiana Di Medicina Interna Sezione Sicilia – Messina–8-9 Novembre 2019 Lettura: “Inibitori di PCSK9: è tempo di ripensare al goal terapeutico?” IV Congresso Congiunto AMD-SID Sicilia 2019 – 24-25 Ottobre 2019 V SESSIONE SID: Nuovi anticoagulanti orali e terapia antiaggregante nel diabete  Lettura: I nuovi anticoagulanti orali SIC: “Prevenzione e trattamento delle malattie cardiovascolari” Lettura “Ipercolesterolemia, quale ruolo per gli integratori?”. Roma 17-18 settembre 2019 SISA 32° congresso nazionale; Sessione: Nuovi biomarcatori e target di danno ateromasico  Lettura “Cellule progenitrici circolanti e proteoglicani”. Bologna, 25-27/11/2018 SISA-SIIA-SIMI: Relazione su invito Spring Meeting Giovani Ricercatori SIIA, SIMI, SISA - Evento Intersocietario a carattere Nazionale Tavola rotonda "Forthcoming Projects" – Rimini 6-7 Aprile 2018 Lettura: “Il Progetto Lipigen” SIMI: VII Congresso Regionale Della Societa’ Italiana Di Medicina Interna Sezione Sicilia – Cefalù – 1-2 Dicembre 2017 Lettura: “Gestione clinica del paziente ad alto rischio” SISA: Congresso annuale della sezione siculo-calabra della Società Italiana dell’Aterosclerosi – Castel di Tusa, 9 ottobre 2017 Lettura: “Cellule progenitrici circolanti e patologia cardiovascolare: cose c’è di nuovo?” SIC-SIEC: XIV International Meeting of Echocardiography. Hilton Giardini Naxos - October, 6–8, 2016 Lettura: “Treatment of arterial hypertension: state of the art” SIMI: La Medicina Interna: ricerca, evidenze scientifiche e metodologia clinica; Vibo Valentia - April, 19-21, 2007. Lettura: “Le ipolipidemie sono sempre protettive?” AICPR – Associazione Italiana di Cardiologia Clinica, Preventiva e Riabilitativa, 11 Congresso regionale, 11.05.2019, Messina Lettura: ESC 2017: novità nella gestione del paziente con fibrillazione atriale SIPMEL – Società Italiana di Patologia medica e Medicina di Laboratorio - sez reg Siciliana – 25 maggio 2018 Lettura: Individuazione di marcatori predittivi di efficacia e di sanguinamento SISA (patr.): “Dislipidemie familiari: un iceberg da scoprire”; I edizione – Messina 12 maggio 2012  Lettura: Dislipidemie familiari e Ipercolesterolemia Lettura: Screening dei pazienti: metodi e strumenti Lettura: Prescrizione: Nota 13 (prima parte) SISA (patr.): “Dislipidemie familiari, un iceberg da scoprire”; II edizione – Giardini Naxos (ME) 3 novembre 2012  Lettura: Dislipidemie familiari e Ipercolesterolemia Lettura: Screening dei pazienti: metodi e strumenti Lettura: Prescrizione: Nota 13 (prima parte) SISA (patr.): La prevenzione nel paziente a rischio cardiovascolare: Facciamo tutti il possibile?” Messina - October, 24, 2015 Lettura: “Il paziente ad elevato rischio CV: Aspetti pratici” SISA-SIIA: Spring Meeting Giovani Ricercatori, Rimini - March, 11-12, 2016 Lettura: “Change in miRs 145, 221 and 222 expression in hypertensive subjects treated with enalapril, losartan or olmesartan” ESH: 26th (European) Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 (European Society of Hypertension) Lettura: “Circulating progenitor cells in hypertension: effectiveness of a treatment with olmesartan in improving cell number and miRs profile besides expected pharmacological effects” Lo slot come Lettura è stato parte del premio conseguito nella sessione poster nel contesto dell’evento (Alberto Ferrari Poster Prize) SISA (patr.): “Before, Il controllo della dislipidemia nella prevenzione CV” – Messina, 20 maggio 2017 (anche Responsabile scientifico) Lettura: “Dislipidemia e Aterosclerosi”

 

Leadership or participation in cooperative panels , including international

·     Local Principal investigator for multicentic the study: Treatment of High and Very high riSk dysplipidemic pAtients for the PreveNTion of cardiOvasculaR Events in Europe - a MultInatioNal ObservatIonal Study (SANTORINI) (CE 45-20, November, 11th, 2020) ·     Local Principal investigator for multicentic the study: LIPIGEN, (Lipid TransPort Disorders Italian Genetic Network)  Supported by: Società Italiana per lo Studio dell'Arteriosclerosi (SISA); Fondazione SISA ; publication list : 1: Pirillo A et al; Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study. Atheroscler Suppl. 2017 Oct;29:17-24. doi: 10.1016/j.atherosclerosissup.2017.07.002. PubMed PMID: 28965616. 2: Averna M et al; LIPIGEN Group. Familial hypercholesterolemia: The Italian Atherosclerosis Society Network (LIPIGEN). Atheroscler Suppl. 2017 Oct;29:11-16. doi: 10.1016/j.atherosclerosissup.2017.07.001. PubMed PMID: 28965615. 3: Casula M. et al; Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study. Atherosclerosis. 2018 Oct;277:413-418. doi: 10.1016/j.atherosclerosis.2018.08.013. dal 16-06-2016 a oggi ·     Local Principal investigator for multicentic the study: PROSISA, (Project Statin Intolerance SISA)  Supported by Società Italiana per lo Studio dell'Arteriosclerosi (SISA); Fondazione SISA. CE 115/16. Publication list: 1.     M Casula, M Gazzotti, F Bonaiti, E OImastroni, M Arca, M Averna, A Zambon, A L Catapano, PROSISA Study Group Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study. J Intern Med. 2020 Dec 1. doi: 10.1111/joim.13219 dal 08-11-2016 a oggi  ·     Participation, National Research Group [Dipartimento di Terapia Intensiva Pediatrica dell'Ospedale Bambino Gesù (Roma), il Centro Mediterraneo di Cardiologia Pediatrica dell'Ospedale Bambino Gesù (Taormina), ed il Dipartimento di Medicina Clinica e Sperimentale dell'Università degli Studi di Messina (Cardiologia e Medicina Interna)]. Publication list:   1.     Oreto L, Mandraffino G, et al; Atrial septal defect morphology and stenting in hypoplastic left heart syndrome after hybrid palliation. Cardiol Young. 2018 Feb;28(2):252-260. -  2.     Manuri L, ..., Mandraffino G, et al; Early hybrid approach and enteral feeding algorithm could reduce the incidence of necrotising enterocolitis in neonates with ductus-dependent systemic circulation. Cardiol Young. 2017 Jan;27(1):154-160.   dal 01-10-2015 a oggi  ·     Particpation, National Research Group ad un [Centro Nemo (NEuroMuscular Omnicentre) ed il Dipartimento di Medicina Clinica e Sperimentale dell'Università degli Studi di Messina (Cardiologia, Medicina Interna) ] Publication list:  1.     Oreto L, Vita GL, Mandraffino G, Carerj S, Calabrò MP, Manganaro R, Cusmà-Piccione M, Todaro MC, Sframeli M, Cinquegrani M, Toscano A, Vita G, Messina S, Zito C., Impaired myocardial strain in early stage of Duchenne muscular dystrophy: its relation with age and motor performance; Acta Myol. 2020 Dec 1;39(4):191-199.  doi: 10.36185/2532-1900-022.  dal 01-10-2016 a oggi  ·     Member, <<SAMS Expert Working Group>>, panel for the management of muscular symptoms onset during statin treatment.  Consensus Paper:  1.     Laufs U et al. Practical aspects in the management of statin-associated muscle symptoms (SAMS). Atheroscler Suppl. 2017 Apr; 26:45-55. doi: 10.1016/S1567-5688(17)30024-7. PubMed PMID: 28434484 (2015-2017). ·     Participation, pharmacological surveillance “FORWARD” (Facilitation of reporting in hospital Ward)  publication list  1.     Adverse Drug Reactions in Hospitalized patients: results of the FORWARD (Facilitation of reporting in hospital Ward) study. C Giardina, ..., G Mandraffino, et al. Frontiers in Pharmacology 2018: 9, 350. doi: 10.3389/fphar.2018.00350 FORWARD: Programma per lo sviluppo del Servizio Sanitario Regionale 2010; Sede direzionale Policlinico Universitario di Messina G. Martino; responsabile del progetto: prof. Vincenzo Arcoraci  dal 01-06-2016 a oggi  ·     Partecipazione ad un Gruppo di Ricerca Nazionale che vede coinvolti: Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Messina (Medicina Interna, Cardiologia), Cardiologia con UTIC dell'Ospedale Pugliese-Ciaccio di Catanzaro; Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Pisa; Dipartimento di Medicina Interna dell'Università di Verona.  Ad oggi l'attività di ricerca del gruppo ha prodotto 6 pubblicazioni a stampa su riviste di rilevanza internazionale (vedi allegato)  dal 01-09-2013 a oggi  ·     LIPIGEN supporting for the study: POSTER (PREVALENCE OF FAMILIAL HYPERCOLESTEROLAEMIA (FH) IN ITALIAN PATIENTS WITH CORONARY ARTERY DISEASE) (promoted by ANMCO and SISA).  2016-2018  ·     Coordination, “Gruppo Giovani Ricercatori SISA”: participation (including Board member) to the National Research group.  Main topic: "Novità nello studio dell'Aterosclerosi e sue complicanze" URL: http://www.sisa.it/index.php?class=Comp& className=Content&op=Show¶m=cid,958, preview,0 . ·     Principal Investigator Center 33017 (Messina) studio multicentrico osservazionale <<20130296>>, "Site Evaluation" , prot CE interaziendale n 15/17  dal 20-02-2017 a oggi  ·     “Unravelling the links among lipid metabolism, immune system and vascular damage in chronic conditions: towards novel biomarkers and therapeutic targets” (reference PI19/00081) submitted by Prof. Dr. Ana Suárez Díaz from the University of Oviedo to the Instituto de Salud Carlos III (Acción Estratégica en Salud 2019) University of Messina - Dipartimento di Medicina Clinica e Sperimentale, Dott. Javier Rodriguez-Carrìo, Prof. Ana Suarez dell’Università di Oviedo. ·     Leadership of an International Research group entitled: "New markers of preclinical cardiovascular impairment in chronic inflammatory disease";  Dipartimento di Medicina Clinica e Sperimentale dell'Università degli Studi di Messina (Medicina Interna, Laboratorio di Biochimica e Biologia Molecolare), Area of Immunology, Department of Functional Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain [Coll: Javier Rodriguez-Carrìo, MSc, PhD; Ana Suarez, Profesor asociado] .  Publication list: ·     1. Lo Gullo A, Rodríguez-Carrio J, Gallizzi R, Imbalzano E, Squadrito G, Mandraffino G. Speckle tracking echocardiography as a new diagnostic tool for an assessment of cardiovascular disease in rheumatic patients. Prog Cardiovasc Dis. 2020 Mar 19. pii: S0033-0620(20)30057-8. doi: 10.1016/j.pcad.2020.03.005. [Epub ahead of print] Review. PubMed PMID: 32201285. 2. Lo Gullo A, Rodríguez-Carrio J, Aragona CO, Dattilo G, Zito C, Suárez A, Loddo S, Atteritano M, Saitta A, Mandraffino G. Subclinical impairment of myocardial and endothelial functionality in very early psoriatic and rheumatoid arthritis patients: Association with vitamin D and inflammation. Atherosclerosis. 2018 Apr;271:214-222. doi: 10.1016/j.atherosclerosis.2018.03.004. Epub 2018 Mar 2. PubMed PMID: 29524864. 3: Mandraffino G, Scicali R, Rodríguez-Carrio J, Savarino F, Mamone F, Scuruchi M, Cinquegrani M, Imbalzano E, Di Pino A, Piro S, Rabuazzo AM, Squadrito G, Purrello F, Saitta A. Arterial stiffness improvement after adding on PCSK9 inhibitors or ezetimibe to high-intensity statins in patients with familial hypercholesterolemia: A Two-Lipid Center Real-World Experience. J Clin Lipidol. 2020 Feb 4. pii: S1933-2874(20)30015-5. doi: 10.1016/j.jacl.2020.01.015. [Epub ahead of print] PubMed PMID: 32111581. 4: Scuruchi M, Potì F, Rodríguez-Carrio J, Campo GM, Mandraffino G. Biglycan and atherosclerosis: Lessons from high cardiovascular risk conditions. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158545. doi: 10.1016/j.bbalip.2019.158545. Epub 2019 Oct 28. Review. PubMed PMID: 31672572. altri dati preliminari sono stati inviati in forma di contributo originale del gruppo di ricerca (abstracts) e accettati a congressi di Società scientifiche nazionale (SISA/SIIA/SIMI, Spring meeting intersocietario 2020) ed internazionali (EAS 2020; EULAR 2020).  dal 14-08-2017 a oggi

 

Published articles	68 (source: Pubmed, Scopus) – May, 20th, 2021.
Metrics	Impact Factor: >200 (Clarivate Analytics);  H-index: 19; citations: 1059 (source: Scopus)
Publication List (International peer-reviewed Journals)	1.   Scuruchi, M., D’Ascola, A, Avenoso, A, Mandraffino, G., Campo, S., Campo, G.M., Endocan, a novel inflammatory marker, is upregulated in human chondrocytes stimulated with IL-1 beta. Molecular and Cellular Biochemistry; Volume 476, Issue 3, March 2021, Pages 1589-1597 2.   Lilia Oreto, Gian Luca Vita, Giuseppe Mandraffino, Scipione Carerj, Maria Pia Calabrò, Roberta Manganaro, Maurizio Cusmà-Piccione, Maria Chiara Todaro, Maria Sframeli, Maria Cinquegrani, Antonio Toscano, Giuseppe Vita, Sonia Messina, Concetta Zito. Impaired myocardial strain in early stage of Duchenne muscular dystrophy: its relation with age and motor performance. Acta Myol. 2020 Dec 1;39(4):191-199. doi: 10.36185/2532-1900-022. eCollection 2020 Dec. 3.   Avenoso A, Campo S, Scuruchi M, Mania M, Innao V, D'Ascola A, Mandraffino G, Allegra AG, Musolino C, Allegra A. Quantitative polymerase Chain reaction profiling of microRNAs in peripheral lymph-monocytes from MGUS subjects. Pathol Res Pract. 2020 Dec 13;218:153317. doi: 10.1016/j.prp.2020.153317. Online ahead of print.PMID: 33360970 4.   Casula M, Gazzotti M, Bonaiti F, OImastroni E, Arca M, Averna M, Zambon A, Catapano AL; PROSISA Study Group. Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study. J Intern Med. 2020 Dec 1. doi: 10.1111/joim.13219. Online ahead of print. PMID: 33259671 5.   D'Ascola A, Scuruchi M, Ruggeri RM, Avenoso A, Mandraffino G, Vicchio TM, Campo S, Campo GM. Hyaluronan oligosaccharides modulate inflammatory response, NIS and thyreoglobulin expression in human thyrocytes. Arch Biochem Biophys. 2020 Nov 15;694:108598. doi: 10.1016/j.abb.2020.108598. Epub 2020 Sep 22. PMID: 32976824 6.   Avenoso A, D'Ascola A, Scuruchi M, Mandraffino G, Campo S, Campo GM. miR146a up-regulation is involved in small HA oligosaccharides-induced pro-inflammatory response in human chondrocytes. Biochim Biophys Acta Gen Subj. 2021 Jan;1865(1):129731. doi: 10.1016/j.bbagen.2020.129731. Epub 2020 Sep 12. PMID: 32931869 7.   Mandraffino, G., Scicali, R., Squadrito, G. Author's reply to: Arterial stiffness improvement after adding on PCSK9 inhibitors in patients with familial hypercholesterolemia, a letter from Papaioannou and colleagues. Journal of Clinical Lipidology, 2020. Volume 14, Issue 4, July - August 2020, Page 543 8.  Mandraffino G, Imbalzano E, Lo Gullo A, Zito C, Morace C, Cinquegrani M, Savarino F, Oreto L, Giuffrida C, Carerj S, Squadrito G. Abnormal left ventricular global strain during exercise-test in young healthy smokers. Sci Rep. 2020 Mar 30;10(1):5700. doi: 10.1038/s41598-020-62428-7. PMID: 32231243 Free Article 9.   Lo Gullo A, Rodríguez-Carrio J, Gallizzi R, Imbalzano E, Squadrito G, Mandraffino G. Speckle tracking echocardiography as a new diagnostic tool for an assessment of cardiovascular disease in rheumatic patients. Prog Cardiovasc Dis. 2020 Mar 19. pii: S0033-0620(20)30057-8. doi: 10.1016/j.pcad.2020.03.005. [Epub ahead of print] Review. PMID: 32201285 10.       Mandraffino G., Scicali R, Rodríguez-Carrio J, Savarino F, Mamone F, Scuruchi M, Cinquegrani M, Imbalzano E, Di Pino A, Piro S, Rabuazzo AM, Squadrito G, Purrello F, Saitta A. Arterial stiffness improvement following adding-on PCSK9 inhibitors or ezetimibe to high intensity statins in familial hypercholesterolemia patients: a two lipid center real-world experience. Journal of Clinical Lipidology. 2020. S1933-2874(20)30015-5. DOI: 10.1016/j.jacl.2020.01.015 11. Scuruchi, M., Potì, F., Rodríguez-Carrio, J., Campo, G.M., Mandraffino, G. Biglycan and atherosclerosis: Lessons from high cardiovascular risk conditions. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2020. 1865(2),158545 12.Avenoso A, Bruschetta G, D Ascola A, Scuruchi M, Mandraffino G, Saitta A, Campo S, Campo GM. Hyaluronan Fragmentation During Inflammatory Pathologies: A Signal That Empowers Tissue Damage. Mini Rev Med Chem. 2020 Sep 6. doi: 20(1), pp. 54-65. PMID: 31490750 13.Avenoso A, Bruschetta G, D'Ascola A, Scuruchi M, Mandraffino G, Gullace R, Saitta A, Campo S, Campo GM. Hyaluronan fragments produced during tissue injury: A signal amplifying the inflammatory response. Arch Biochem Biophys. 2019 Mar 15;663:228-238. doi: 10.1016/j.abb.2019.01.015. Epub 2019 Jan 19. Review. PubMed PMID: 30668938.  14.Basile G, Catalano A, Mandraffino G, Maltese G, Alibrandi A, Ciancio G, Brischetto D, Morabito N, Lasco A, Cesari M. Frailty modifications and prognostic impact in older patients admitted in acute care. Aging Clin Exp Res. 2019 Jan;31(1):151-155. doi: 10.1007/s40520-018-0989-7. Epub 2018 Jun 26. PubMed PMID:29946755. 15.Scuruchi M, D'Ascola A, Avenoso A, Mandraffino G., Campo S., Campo GM. Serglycin as part of IL-1β induced inflammation in human chondrocytes. Arch Biochem Biophys. 2019 Jul 15;669:80-86. doi: 10.1016/j.abb.2019.05.021. Epub 2019 May 27. PMID: 31145901 16.Mandraffino G, Saitta A. Endothelial and Circulating Progenitor Cells: Between Diseases and Therapies. Curr Med Chem. 2018;25(35):4476-4477. Doi:10.2174/092986732535181026143801. PubMed PMID: 30563440. 17. Imbalzano E, Vatrano M, Ghiadoni L, Mandraffino G, Dalbeni A, Khandheria BK, Costantino R, Trapani G, Manganaro R, Cusmà Piccione M, Carerj S, Ceravolo R, Saitta A, Zito C. Arterial stiffness and mitral regurgitation in arterial hypertension: an intriguing pathophysiological link. Vascul Pharmacol. 2018 Dec;111:71-76. doi: 10.1016/j.vph.2018.10.007. Epub 2018 Oct 22. PubMed PMID:30359778.  18.       Casula M, Olmastroni E, Pirillo A, Catapano AL; MEMBERS OF THE LIPIGEN STEERING COMMETTEE; PRINCIPAL INVESTIGATORS: Coordinator center; Participant Centers; Participant Laboratories; COLLABORATORS; STUDY CENTRAL LABORATORY AND ANALYSIS GROUP. Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study. Atherosclerosis. 2018 Oct;277:413-418. doi: 10.1016/j.atherosclerosis.2018.08.013. PubMed PMID: 30270079. 19.Lo Gullo A, Aragona CO, Scuruchi M, Versace AG, Saitta A, Imbalzano E, Loddo S, Campo GM, Mandraffino G. Endothelial progenitor cells and rheumatic disease modifying therapy. Vascul Pharmacol. 2018 Sep;108:8-14. doi:10.1016/j.vph.2018.05.007. Epub 2018 May 26. Review. PubMed PMID: 29842927. 20.      Muto P, Lo Gullo A, Mandraffino G, Loddo S, Atteritano M. High levels of serum sclerostin and DKK1 in a case of Klippel-Trénaunay syndrome. Osteoporos Int. 2018 Jul;29(7):1679-1681. doi: 10.1007/s00198-018-4563-0. Epub 2018 May 17. PubMed PMID: 29774401. 21.Giardina C, Cutroneo PM, Mocciaro E, Russo GT, Mandraffino G, Basile G, Rapisarda F, Ferrara R, Spina E, Arcoraci V. Adverse Drug Reactions in Hospitalized Patients: Results of the FORWARD (Facilitation of Reporting in Hospital Ward) Study. Front Pharmacol. 2018 Apr 11;9:350. doi: 10.3389/fphar.2018.00350. eCollection 2018. PubMed PMID: 29695966; PubMed Central PMCID: PMC5904209. 22.       D'Ascola A, Scuruchi M, Avenoso A, Bruschetta G, Campo S, Mandraffino G, Campo GM. Serglycin is involved in inflammatory response in articular mouse chondrocytes. Biochem Biophys Res Commun. 2018 May 15;499(3):506-512. doi:10.1016/j.bbrc.2018.03.178. Epub 2018 Mar 31. PubMed PMID: 29588174.  23.       Lo Gullo A, Rodríguez-Carrio J, Aragona CO, Dattilo G, Zito C, Suárez A, Loddo S, Atteritano M, Saitta A, Mandraffino G. Subclinical impairment of myocardial and endothelial functionality in very early psoriatic and rheumatoid arthritis patients: Association with vitamin D and inflammation. Atherosclerosis. 2018 Apr;271:214-222. doi: 10.1016/j.atherosclerosis.2018.03.004. Epub 2018 Mar 2. PubMed PMID: 29524864. 24.       Imbalzano E, Vatrano M, Quartuccio S, Ceravolo R, Ciconte VA, Rotella P, Pardeo R, Trapani G, De Fazio P, Segura-Garcia C, Costantino R, Saitta A, Mandraffino G. Effect of type D personality on smoking status and their combined impact on outcome after acute myocardial infarction. Clin Cardiol. 2018 Mar;41(3):321-325. doi: 10.1002/clc.22865. Epub 2018 Feb 19. PubMed PMID:29457844. 25.       Avenoso A, D'Ascola A, Scuruchi M, Mandraffino G, Calatroni A, Saitta A, Campo S, Campo GM. Hyaluronan in experimental injured/inflamed cartilage: In vivo studies. Life Sci. 2018 Jan 15;193:132-140. doi: 10.1016/j.lfs.2017.11.006. Epub 2017 Nov 7. Review. PubMed PMID: 29126884. 26.       Avenoso A, D'Ascola A, Scuruchi M, Mandraffino G, Calatroni A, Saitta A, Campo S, Campo GM. The proteoglycan biglycan mediates inflammatory response by activating TLR-4 in human chondrocytes: Inhibition by specific siRNA and high polymerized Hyaluronan. Arch Biochem Biophys. 2018 Jan 13;640:75-82. doi: 10.1016/j.abb.2018.01.007. [Epub ahead of print] PubMed PMID: 29339093. 27.       Avenoso A, D'Ascola A, Scuruchi M, Mandraffino G, Calatroni A, Saitta A, Campo S, Campo GM. Hyaluronan in the experimental injury of the cartilage: biochemical action and protective effects. Inflamm Res. 2018 Jan;67(1):5-20. doi: 10.1007/s00011-017-1084-9. Epub 2017 Aug 12. Review. PubMed PMID: 28803264. 28.      Basile G, Catalano A, Mandraffino G, Maltese G, Alibrandi A, Ciancio G, Lasco A, Cesari M. Relationship between blood pressure and frailty in older hypertensive outpatients. Aging Clin Exp Res. 2017 Oct;29(5):1049-1053. doi: 10.1007/s40520-016-0684-5. Epub 2016 Nov 21. PubMed PMID: 27873101. 29.       Pirillo A, Garlaschelli K, Arca M, Averna M, Bertolini S, Calandra S, Tarugi P, Catapano AL; LIPIGEN Group. Spectrum of mutations in Italian patients with familial hypercholesterolemia: New results from the LIPIGEN study. Atheroscler Suppl. 2017 Oct;29:17-24. doi: 10.1016/j.atherosclerosissup.2017.07.002. PubMed PMID: 28965616. 30.      Averna M, Cefalù AB, Casula M, Noto D, Arca M, Bertolini S, Calandra S, Catapano AL, Tarugi P; LIPIGEN Group. Familial hypercholesterolemia: The Italian Atherosclerosis Society Network (LIPIGEN). Atheroscler Suppl. 2017 Oct;29:11-16. doi: 10.1016/j.atherosclerosissup.2017.07.001. PubMed PMID: 28965615.  31.Oreto L, Mandraffino G, Manuri L, Saitta MB, Agati S, Zito C, Iorio FS, Carerj S, Guccione P. Atrial septal defect morphology and stenting in hypoplastic left heart syndrome after hybrid palliation. Cardiol Young. 2017 Sep 11:1-9. doi: 10.1017/S1047951117001792. [Epub ahead of print] PubMed PMID: 28889828.  32.       Laufs U, Filipiak KJ, Gouni-Berthold I, Catapano AL; SAMS expert working group (Mandraffino G; Benlian P). Practical aspects in the management of statin-associated muscle symptoms (SAMS). Atheroscler Suppl. 2017 Apr;26:45-55. doi: 10.1016/S1567-5688(17)30024-7. PubMed PMID: 28434484. 33.       Mandraffino G, Cairo V, Saitta A. Current challenges on circulating progenitor cells: Could their number predict oncoming diseases? Atherosclerosis. 2017 Mar 31. pii: S0021-9150(17)30140-5. doi: 10.1016/j.atherosclerosis.2017.03.037. [Epub ahead of print] PubMed PMID: 28389015. 34.       Mandraffino G, Aragona CO, Scuruchi M, Mamone F, D'Ascola A, Alibrandi A, Cinquegrani M, Morace C, Oreto L, Saitta C, Mormina E, Carerj S, Saitta A, Imbalzano E. Biglycan expression, earlier vascular damage and pro-atherogenic profile improvement after smoke cessation in young people. Atherosclerosis. 2017 Jan 16;257:109-115. doi: 10.1016/j.atherosclerosis.2017.01.012. [Epub ahead of print] PubMed PMID: 28131044.  35.       Mandraffino G, Aragona CO, Basile G, Cairo V, Mamone F, Morace C, D'Ascola A, Alibrandi A, Lo Gullo A, Loddo S, Saitta A, Imbalzano E. CD34+ cell count predicts long lasting life in the oldest old. Mech Ageing Dev. 2017 Mar 16. pii: S0047-6374(17)30061-1. doi: 10.1016/j.mad.2017.03.003. [Epub ahead of print] PubMed PMID: 28322848. 36.       Mandraffino G, Aragona CO, Cairo V, Scuruchi M, Lo Gullo A, D'Ascola A, Alibrandi A, Loddo S, Quartuccio S, Morace C, Mormina E, Basile G, Saitta A, Imbalzano E. Circulating progenitor cells in hypertensive subjects: Effectiveness of a treatment with olmesartan in improving cell number and miR profile in addition to expected pharmacological effects. PLoS One. 2017 Mar 16;12(3):e0173030. doi: 10.1371/journal.pone.0173030. eCollection 2017. PubMed PMID: 28301500; PubMed Central PMCID: PMC5354372. 37.       Manuri L, Morelli S, Agati S, Saitta MB, Oreto L, Mandraffino G, Iannace E, Iorio FS, Guccione P. Early hybrid approach and enteral feeding algorithm could reduce the incidence of necrotising enterocolitis in neonates with ductus-dependent systemic circulation. Cardiol Young. 2017 Jan;27(1):154-160. doi: 10.1017/S1047951116000275. PubMed PMID: 28281412. 38.      Imbalzano E, Vatrano M, Quartuccio S, Di Stefano R, Aragona CO, Mamone F, D'Ascola A, Scuruchi M, Felice F, Trapani G, Alibrandi A, Ciconte VA, Ceravolo R, Saitta A, Mandraffino G. Clinical impact of angiotensin I converting enzyme polymorphisms in subjects with resistant hypertension. Mol Cell Biochem. 2017 Feb 11. doi: 10.1007/s11010-017-2957-5. [Epub ahead of print] PubMed PMID: 28190172. 39.       Lo Gullo A, Mandraffino G, Aragona CO, Molica Colella A, Saitta A, Imbalzano E. Subcutaneous administration of tocilizumab is effective in myointimal hyperplasia remodelling in refractory Takayasu arteritis. Reumatismo. 2017 Dec 21;69(4):184-188. doi: 10.4081/reumatismo.2017.1013. PMID: 29320845  40.      Mandraffino G, Aragona CO, Imbalzano E. Surrogate markers of HDL functionality and arterial stiffening: Which role in rheumatoid arthritis? Atherosclerosis. 2016 Jul 5. pii: S0021-9150(16)30301-X. doi: 10.1016/j.atherosclerosis.2016.07.002. 41.Caterina Oriana Aragona, Egidio Imbalzano, Federica Mamone, Valentina Cairo, Alberto Lo Gullo, Angela D’Ascola, Maria Adriana Sardo, Michele Scuruchi, Giorgio Basile, Antonino Saitta, and Giuseppe Mandraffino. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease, Stem Cells International Volume 2016 (2016), Article ID 8043792, 12 pages; DOI: 10.1155/2016/8043792. 42.       Egidio Imbalzano, Giuseppe Mandraffino, Marco Casciaro, Sebastiano Quartuccio, Antonino Saitta, Sebastiano Gangemi. Pathophysiological mechanism and therapeutic role of S100 proteins in cardiac failure: a systematic review. Heart Fail Rev. DOI: 10.1007/s10741-016-9529-8. 43.       Lo Gullo A, Aragona CO, Ardesia M, Versace AG, Cascio A, Saitta A, Mandraffino G. A Strongyloides stercoralis infection presenting as arthritis of sternoclavicular joint. Mod Rheumatol. 2016 Nov;26(6):981-983. doi:10.3109/14397595.2015.1132954. Epub 2016 Feb 16. PubMed PMID: 26709048. 44.       Minciullo PL, Catalano A, Mandraffino G, Casciaro M, Crucitti A, Maltese G, Morabito N, Lasco A, Gangemi S, Basile G. Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity. Arch Immunol Ther Exp (Warsz). 2015 Dec 12. [Epub ahead of print] PubMed PMID: 26658771. 45.       Lo Gullo A, Mandraffino G, Bagnato G, Aragona CO, Imbalzano E, D'Ascola A, Rotondo F, Cinquegrani A, Mormina E, Saitta C, Versace AG, Sardo MA, Lo Gullo R, Loddo S, Saitta A. Vitamin D Status in Rheumatoid Arthritis: Inflammation, Arterial Stiffness and Circulating Progenitor Cell Number. PLoS One. 2015 Aug 4;10(8):e0134602. doi: 10.1371/journal.pone.0134602. eCollection 2015. PubMed PMID: 26241902; PubMed Central PMCID: PMC4524708. 46.      Imbalzano E, Vatrano M, Mandraffino G, Ghiadoni L, Gangemi S, Bruno RM, Ciconte VA, Paunovic N, Costantino R, Mormina EM, Ceravolo R, Saitta A, Dattilo G. Arterial stiffness as a predictor of recovery of left ventricular systolic function after acute myocardial infarction treated with primary percutaneous coronary intervention. Int J Cardiovasc Imaging. 2015 Dec;31(8):1545-51. doi: 10.1007/s10554-015-0733-8. Epub 2015 Aug 4. PubMed PMID: 26239135. 47.       Basile G, Catalano A, Mandraffino G, Crucitti A, Ciancio G, Morabito N, Lasco A. Cognitive Impairment and Slow Gait Speed in Elderly Outpatients with Arterial Hypertension: The Effect of Blood Pressure Values. J Am Geriatr Soc. 2015 Jun;63(6):1260-1. doi: 10.1111/jgs.13495. PubMed PMID: 26096407. 48.      Vatrano M, Dattilo G, Mandraffino G, Gangemi S, Ciconte VA, Quartuccio S, Ceravolo R, Imbalzano E. A quick bailout ongoing of cardiogenic shock and iatrogenic dissection of the left main coronary artery. Int J Cardiol. 2015 Apr 1;184:473-4. doi: 10.1016/j.ijcard.2015.03.001. Epub 2015 Mar 3. PubMed PMID: 25756567.  49.       Mandraffino G, Imbalzano E, Mamone F, Aragona CO, Lo Gullo A, D'Ascola A, Alibrandi A, Cinquegrani A, Mormina E, Versace A, Basile G, Sardo MA, Cinquegrani M, Carerj S, Saitta A. Biglycan expression in current cigarette smokers: a possible link between active smoking and atherogenesis. Atherosclerosis. 2014 Dec;237(2):471-9. doi: 10.1016/j.atherosclerosis.2014.10.024. Epub 2014 Oct 18. PubMed PMID: 25463076. 50.      Lo Gullo A, Mandraffino G, Imbalzano E, Mamone F, Aragona CO, D'Ascola A, Loddo S, Cinquegrani A, Alibrandi A, Mormina E, Bagnato G, Lo Gullo R, Sardo MA, Saitta A. Toll-like receptor 3 and interleukin 1β expression in CD34+ cells from patients with rheumatoid arthritis: association with inflammation and vascular involvement. Clin Exp Rheumatol. 2014 Nov-Dec;32(6):922-9. Epub 2014 Nov 7. PubMed PMID: 25436985. 51.Imbalzano E, Scarpelli M, Mandraffino G, Creazzo M, Lizio G, Trapani G, Dattilo G, Dalbeni A, Tomasello C, Sardo MA, Saitta A. Combination therapy with aliskiren versus ramipril or losartan added to conventional therapy in patients with type 2 diabetes mellitus, uncontrolled hypertension and microalbuminuria. J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):956-64. doi: 10.1177/1470320314530018. Epub 2014 Jul 27. PubMed PMID: 25070350. 52.  Imbalzano E, Mandraffino G, Ceravolo R, Di Stefano R, Saitta A. Renal denervation rapidly restores circulating proangiogenic hematopoietic cells in patients affected by drug-resistant hypertension. Int J Cardiol. 2014 May 15;173(3):591-2. doi: 10.1016/j.ijcard.2014.03.100. Epub 2014 Mar 21. PubMed PMID: 24698255. 53.  Imbalzano E, Casale M, D'Angelo M, Mandraffino G, Giugno V, Di Bella G, Carerj S, Dattilo G. Cardiovascular risk and psoriasis: a role in clinical cardiology? Angiology. 2015 Feb;66(2):101-3. doi: 10.1177/0003319714527339. Epub 2014 Mar 25. Review. PubMed PMID: 24671131. 54.  Mandraffino G, Imbalzano E, Sardo MA, D'Ascola A, Mamone F, Lo Gullo A, Alibrandi A, Loddo S, Mormina E, David A, Saitta A. Circulating progenitor cells in hypertensive patients with different degrees of cardiovascular involvement. J Hum Hypertens. 2014 Sep;28(9):543-50. doi: 10.1038/jhh.2014.7. Epub 2014 Feb 20. PubMed PMID: 24553637. 55.  Mandraffino G, Dalbeni A, Paunovic N, Mormina EM, Imbalzano E. Radiation-induced heart and vessel atherosclerosis disease. Int J Cardiol. 2014 Mar 15;172(2):505-6. doi: 10.1016/j.ijcard.2014.01.059. Epub 2014 Jan 23. PubMed PMID: 24485624. 56.  Imbalzano E, Saitta A, Lamari A, Trapani G, Lizio G, Creazzo M, Mandraffino G, Scarano M, Dattilo G. [Echo-Doppler evaluation of recent onset chronic venous insufficiency in elderly patients: does the heart have a role?]. Recenti Prog Med. 2013 Nov;104(11):569-73. doi: 10.1701/1370.15226. Italian. PubMed PMID: 24336618. 57.  Lo Gullo A, Mandraffino G, Sardo MA, D'Ascola A, Mamone F, Loddo S, Alibrandi A, Imbalzano E, Mandraffino R, Mormina E, Saitta C, Lo Gullo R, David A, Saitta A. Circulating progenitor cells in rheumatoid arthritis: association with inflammation and oxidative stress. Scand J Rheumatol. 2014;43(3):184-93. doi: 10.3109/03009742.2013.836564. Epub 2013 Dec 9. PubMed PMID: 24313545. 58. Imbalzano E, Creazzo M, Mandraffino G, Sardo MA, Saitta A. Treatment failure of low molecular weight heparin in post-surgery orthopedic case. Int J Cardiol. 2013 Nov 5;169(3):e36-7. doi: 10.1016/j.ijcard.2013.08.109. Epub 2013 Sep 8. PubMed PMID: 24063927. 59.  Mandraffino G, Sardo MA, Riggio S, D'Ascola A, Alibrandi A, Saitta C, Versace A, Castaldo M, Mormina E, Imbalzano E, Cinquegrani M, Bonaiuto M, David A, Saitta A. Circulating progenitor cells and the elderly: a seven-year observational study. Exp Gerontol. 2012 May;47(5):394-400. doi: 10.1016/j.exger.2012.03.007. Epub 2012 Mar 17. PubMed PMID: 22449458. 60. Imbalzano E, Zito C, Carerj S, Oreto G, Mandraffino G, Cusmà-Piccione M, Di Bella G, Saitta C, Saitta A. Left ventricular function in hypertension: new insight by speckle tracking echocardiography. Echocardiography. 2011 Jul;28(6):649-57. doi: 10.1111/j.1540-8175.2011.01410.x. Epub 2011 Jun 15. PubMed PMID: 21676016. 61.  Mandraffino G, Sardo MA, Riggio S, Loddo S, Imbalzano E, Alibrandi A, Saitta C, Cinquegrani M, Mormina EM, Saitta A. Circulating progenitor cells are increased in newly diagnosed untreated hypertensive patients with arterial stiffening but normal carotid intima-media thickness. Hypertens Res. 2011 Jul;34(7):876-83. doi: 10.1038/hr.2011.56. Epub 2011 May 19. PubMed PMID: 21593737. 62. Cascio A, Mandraffino G, Cinquegrani M, Delfino D, Mandraffino R, Romeo O, Criseo G, Saitta A. Actinomadura pelletieri mycetoma--an atypical case with spine and abdominal wall involvement. J Med Microbiol. 2011 May;60(Pt 5):673-6. doi: 10.1099/jmm.0.027862-0. Epub 2011 Jan 20. Review. PubMed PMID: 21252272. 63. Mandraffino G, Sardo MA, Riggio S, D'Ascola A, Loddo S, Alibrandi A, Saitta C, Imbalzano E, Mandraffino R, Venza M, Mormina EM, David A, Saitta A. Smoke exposure and circulating progenitor cells: evidence for modulation of antioxidant enzymes and cell count. Clin Biochem. 2010 Dec;43(18):1436-42. doi: 10.1016/j.clinbiochem.2010.09.023. Epub 2010 Sep 29. PubMed PMID: 20888331. 64. Riggio S, Mamone F, Mandraffino G, Maimone S, Alibrandi A, Manti L, Saitta C, Tripodi PF, Sardo MA, Squadrito G, Saitta A. Assessment of liver stiffness in subjects affected by familial combined hyperlipidaemia with hepatic steatosis. Eur J Clin Invest. 2010 Aug;40(8):722-8. doi: 10.1111/j.1365-2362.2010.02323.x. Epub 2010 Jun 14. PubMed PMID: 20561029. 65.  Sardo MA, Mandraffino G, Riggio S, D'Ascola A, Alibrandi A, Saitta C, Imbalzano E, Castaldo M, Cinquegrani M, Saitta A. Effects of the angiotensin II receptor blocker losartan on the monocyte expression of biglycan in hypertensive patients. Clin Exp Pharmacol Physiol. 2010 Sep;37(9):933-8. doi: 10.1111/j.1440-1681.2010.05407.x. Epub 2010 May 24. PubMed PMID: 20497421. 66. Riggio S, Mandraffino G, Sardo MA, Iudicello R, Camarda N, Imbalzano E, Alibrandi A, Saitta C, Carerj S, Arrigo T, Saitta A. 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Aknowledgments
Awarded oral Communication	27th (European) Meeting on Hypertension and Cardiovascular Protection Milan (Italy), June 16-19, 2017 (ESH): Efficacy of monoclonal antibodies anti-proprotein convertase subtilisin-kexin type 9 in improving lipid profile and arterial stiffness in patients affected by familial hypercholesterolemia; Oral Communication
Accommodation Grant Prize	26th (European) Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 (ESH): “Circulating progenitor cells in hypertension: effectiveness of a treatment with olmesartan in improving cell number and miRs profile besides expected pharmacological effects” Presenting author
Award for Best Poster Session  “Alberto Ferrari Poster Prize”	26th (European) Meeting on Hypertension and Cardiovascular Protection Paris (France), June 10-13, 2016 (ESH): “Circulating progenitor cells in hypertension: effectiveness of a treatment with olmesartan in improving cell number and miRs profile besides expected pharmacological effects” Presenting author
Best original contribution	Spring Meeting SISA/SIIA, Rimini, 11-12 March, 2016; section: Poster Contribution: AT1R blockade by Losartan as well as smoking cessation reduce Biglycan expression in uncomplicated subjects Presenting author
Travel Grant Prize	EAS European Congress, Innsbruck, May 29- June 1 2016; section: Poster Three original contributions Presenting author
Travel Grant Prize	EAS European Congress, Innsbruck, May 29- June 1 2016; section: Poster Three original contributions Co-author
Young Researcher Prizes (SISA Travel Grant)	Edizioni Congresso Nazionale SISA: 2006; 2007; 2009; 2010; 2011; 2012; 2013; 2014; 2015; 2016; 2017; 2018; 2019. Quattro volte premiato come presenting first author Sei volte premiato come non-presenting first author (co-primo) Dieci volte premiato come study coordinator author Nove volte premiato come non-presenting author
Last Update:  May, 20th, 2021

 
Including: autorizzazione al trattamento dei dati personali e la dichiarazione di veridicità dei dati secondo il D.P.R. n.445/2000.