Obiettivi Formativi

Obiettivo dell'insegnamento della Farmacologia è l'apprendimento delle conoscenze di base sulle interazioni tra i farmaci e l'organismo umano. Saranno fornite le informazioni essenziali riguardanti la farmacocinetica (destino del farmaco nell'organismo), la farmacodinamica (meccanismo d'azione ed effetti farmacologici), l'efficacia e la sicurezza delle principali classi di farmaci. Saranno illustrati i principi generali della farmacovigilanza. Fornire elementi necessari ad impostare un corretto primo soccorso focalizzando i principi di rianimazione cardiopolmonare e traumatologica alla luce delle attuali linee-guida internazionali (Modulo Rianimazione).

Learning Goals

The aim of the course is to learn basic knowledge on the interactions between drugs and the human body. Essential information regarding pharmacokinetics (fate of the drug in the body), pharmacodynamics (mechanism of action and pharmacological effects), application and safety of the main classes of drugs will be provided. The general principles of pharmacovigilance will be illustrated. To provide essential information to set up first aid focusing principles of cardiopulmonary resuscitation and trauma in light of current international guidelines (Resuscitation).

Metodi didattici

Lezioni frontali

Teaching Methods

*teaching, lessons

Prerequisiti

Ammissione al CL in SMSS e propedeudicità

Prerequisites

*Admission to the University Degree Course in Sports Science and Healthcare and prerequisites

Verifiche dell'apprendimento

Esame orale

Assessment

*End-course exam

Programma del Corso

1. Principi generali di Farmacologia 2. Farmacocinetica a. assorbimento b. distribuzione c. metabolismo d. escrezione 3. Farmacodinamica a. Bersagli biologici dei farmaci b. Definizione e classificazione dei recettori c. Interazioni farmaco-recettore d. Agonismo/antagonismo recettoriale Classificazione delle Reazioni avverse

Course Syllabus

Definitions of Pharmacology and Drugs. Branches of pharmacology: pharmacokinetics, pharmacodynamics, PHARMACOKINETICS Mechanisms of action of drugs through the biological membranes, physico-chemical factors. Absorption and routes of administration of drugs. Pharmaceutical forms. Distribution and binding to plasma and tissue protein. Redistribution. Drug biotransformation. Factors that influence the biotransformation: induction, inhibition, genetic polymorphism. Routes of excretion. PHARMACODYNAMICS Mechanism of action of drugs. Drug’s receptors. Physiological receptors (for hormones, neurotransmitters, growth factors, etc.). Macromolecular structure. Membrane and intracellular receptors. Ionotropic and metabotropic receptors (examples). Ion channels. Systems of signal transduction within the cell. Protein G. Second messengers. Receptor desensitization. Down and up regulation. Drug-receptor interactions. Structure-activity relationships. Dose-response curves. Receptor theory. Maximum effect. Affinity, efficacy, intrinsic activity. Effective Dose 50 (DE50). Full and partial agonists, antagonists (competitive and non-competitive), inverse agonists. Two-state model. Allosteric modulators. Classification of drug adverse reactions