Obiettivi Formativi

Conoscenza ed applicazione dei metodi di analisi qualitativa dei farmaci inorganici/organici riportati nella Farmacopea Europea.

Learning Goals

Knowledge and application of methods for the qualitative analysis of inorganic drugs included in the European Pharmacopoeia.

Teaching Methods

Frontal lectures (32 hours) and practical individual laboratory activities (48 hours). Didactic instruments Lectures: Overhead projector, videoprojector and laptop Laboratory activities: practice laboratory in single work bench; semi-micro analysis glasswares, reagents and chemicals, laboratory equipments, and safety equipments.

Prerequisiti

Propedeuticità: Chimica analitica

Prerequisites

Propaedeutics teachings: Analytical chemistry

Assessment

The oral examination and laboratory individual tests. The final examination aims to evaluate the achievement of didactic activities: - to know and to be able to characterize cations and anions from a reaction mixture. - to know and to be able to apply practically the specific reactions to identify inorganic elements, according to the methods of FU end Eur. Pharm.. - to know pharmaceutics aspects as well as toxicity of inorganic drugs. - to demonstrate of being able to learn the main topics of the course, dealing with the next teachings.

Programma del Corso

Parte teorica: Introduzione all'analisi farmaceutica; illustrazione della Farmacopea Ufficiale Italiana (FU) e Farmacopea Eur. (Ph. Eur). Metodi strumentali e metodi sistematici chimici: analisi per via Secca o per via Umida. Caratteristiche chimico-fisiche di sostanze di interesse farmaceutico. Sostanze riportate in FU e Ph. Eur: generalità, attività biologica-tossicologica. Reattività chimica degli ioni e loro ricerca. Parte pratica:Esercitazioni di laboratorio a posto singolo. Norme di sicurezza in laboratorio e sulle attrezzature di laboratorio. Tecniche di separazione, isolamento e purificazione dei prodotti di reazione Analisi chimica qualitativa semi-micro di cationi ed anioni inorganici/organici anche in miscela, utilizzando prevalentemente le metodologie previste dall’analisi qualitativa classica di sostanze di interesse farmaceutico (FU e Ph. Eur).

Course Syllabus

Lessons - Introduction to qualitative methods of drug analysis. Preliminary operations in chemical analysis. Italian Pharmacopoeia (FU) and European Pharmacopoeia (Ph. Eur.). Inorganic ions of pharmaceutical and toxicological interest: chemical properties, identification reactions, pharmacological and toxicological properties. Laboratory activities - General rules of good behaviour and safety in laboratory. Accident prevention. Safety equipments. Acquisition of laboratory practice for some main operations (solubility, dilution, filtration and centrifugation) to the identification of inorganic drugs. Identification reactions of inorganic ions. Preliminary dry tests. Ion separation into analytical groups. Identification and tests of inorganic compounds of FU and Ph. Eur.